Industrial & Pharmaceutical Intermediates Contract Manufacturing (CMO)
Industrial & Pharmaceutical Intermediates Contract Manufacturing (CMO)
Pharmaceutical Intermediates are used for the benefit of human and animal health. They are used to manufacture Active Pharmaceutical Ingredients which are used for the manufacturing finished medicines/dosage. India is a major producer of active pharmaceutical ingredients contributing to the wellbeing of both human and animal population of the world. Avanza Trade was established in 2022. We wish to be involved in the contract manufacturing of drug intermediates (CMO) or industrial chemicals to improve health and living conditions of our world and its citizens.
Services
1. The formulations and quality parameters set by your company will be followed. The raw materials and other ingredients will be procured from your certified vendors or of certified quality standards set by you for the contract manufacturing facility.
2. We will build a state of the art facility that will have advanced machineries such as:
a. Stainless Steel Reactors – For Chemical Reactions that are basic in nature
b. Glass Line Reactors – For Chemical Reactions that are acidic in nature
c. Pressure Reactors – Pressure reactors (stirred autoclaves) are used for various chemical reactions and other applications under pressure, such as hydrogenation, polymerization, catalyst screening and corrosion testing.
d. SS Centrifuge – A centrifuge is used to separate particles suspended in a liquid according to particle size and density, viscosity of the medium, and rotor speed. Within a solution, gravitational force will cause particles of higher density than the solvent to sink, and those less dense than the solvent to float to the top.
e. Tray Dryers
f. RCVD
g. Cryogenic reactor
h. Miscellaneous – Cooling Tower, Compressed Air Unit, Steam Jet Vacuum Pumps, Oil Ring Vacuum Pumps, Water System, HPLC and GC with 21 CFR compliance, Semi Micro Balance, KF Titrator, ph Meter, Melting Range, Conductivity and TDS Meter, UV Cabinet, Digital Ultrasonic Bath, Muffle Furnace, Hot Air Oven and Vacuum Oven, Cyclic Mixer, Hot Plate and Magnetic Stirrer.
3. Quality testing and simulation will also be done by our company to provide the best quality components
Target API’s and their therapeutic area
Types of Therapeutic Categories :-
| Anti-Cancer/ Oncology | Anti-ALS | Anti-Epileptic | Anti-Scabies |
| Cardiovascular | Anti-Alzheimer's | Anti-Gout | Anti-Schizophrenic |
| Central Nervous System (CNS | Anti-Anaemic | Anti-Hair Loss | Anti-Smoking |
| Dermatology | Anti-Angina | Anti-hypertensive | Antispasmodic |
| Gastro-Intestinal - GI | Anti-Arthritis | Anti-hyperuricemia | Anti-Viral |
| Musculoskeleta | Anti-Asthma | Anti-Infective | Pulmonary Arterial Hypertension - PAH |
| Ophthalmology | Anti-Coagulant | Anti-Malarial | Generalized Anxiety Disorder |
| Respiratory | Anti-Constipation | Anti-Migraine | H2-receptor antagonists |
| Anaesthetic Supportive Care | Anti-Diabetic | Anti-Osteoporosis | Hereditary Angioedema |
| Anti-Allergy | Antiemetic | Anti-Parathyroid | Hormones |
| Anti-Parkinson's | ADHD | Lipid modifying agents | Insomnia |
| Anti-Platelet | Benign Prostatic Hyperplasia - BPH | Major Depressive Disorder | Weight Management |
| Anti-Psoriasis | Bipolar-Disorder | Multiple Sclerosis -MS | Proton Pump Inhibitors (PPI) |
| Nonalcoholic steatohepatitis - NASH | Overactive Bladder -OAB | Pain Management | Primary Biliary Cirrhosis - PBC |
Types of Dosage :-
| Powder | Injectable | Liquid | Topical |
| Nasal | Ophthalmic | Oral Solids |
Target Therapeutic Areas and their molecules :-
1. Oncology: -amide, -abine, -idine, -domide, -nib, -rib, -lib (Kinase Inhibitors)
2. Cardiovascular: -pril, -dipine, -sartan, -lol(Blood pressure/beta blockers), -durone, – tan(some)
3. CNS: –pine, -cetam, -gine
4. Anti-coagulant: -ban, -tram (not all)
5. Proton Pump Inhibitors: -prazole
6. Antiviral: -vir
7. Antifungal: -azole
8. Diabetes: -gliptin
Types of Therapeutic Categories :-
| Oncology Drugs - API | ||||
| Bicalutamide | Enzalutamide | Capecitabine | Lenalidomide | Afatinib |
| Axitinib | Bosutinib | Ceritinib | Dabrafenib | Dasatinib |
| Erlotinib | Ibrutinib | Imatinib | Lapatinib | Nilotinib |
| Pazopanib | Regorafenib | Sorafenib | Sunitinib | Olaparib |
| Olaparib | ||||
| Cardiovascular Drugs - API | ||||
| Azelnidipine | Benidipine | Dipine | Enalapril | Perindopril |
| Captopril | Azilsartan | Losartan | Olmesartan | Telmisartan |
| Valsartan | Betaxolol | Carvedilol | Ambrisentan | Bosentan |
| Macitentan | Tolvaptan | |||
| CNS Drugs - API | ||||
| Oxcarbazepine | Quetiapine | Eslicarbazepine | Brivaracetam | Levetiracetam |
| Lamotrigine | ||||
| Anticoagulant Drugs - API | ||||
| Apixaban | Argatroban | Edoxaban | Rivaroxaban | |
| Diabetes | ||||
| Alogliptin | Anagliptin | Linagliptin | Saxagliptin | Sitagliptin |
| Teneligliptin | Vildagliptin | |||
Target Industrial Chemicals that we want to manufacture for :-
| Agro-Chemicals | Architectural Paints and Coatings | Automotive and Transportation | General Chemicals |
| Construction | Dispersion and Resins | Electronics and Electrics | Energy and Resources |
| Furniture and Wood | Packaging and Print | Paper Coatings and Carpet | Plastics and Rubbe |
| Textile, Leather and Footwear | Adhesives |
Note:- As per the client’s requirement and our capacity we are ready to manufacture other finished products as well.
Final Setup
This segment talks about the last few final steps to be taken for a successful establishment of the state of the art facility:
1. Manpower: Our team will focus on reliable people on and off the facility for the smoothest and cost effective production. For example:
a. Shop floor Engineers: The core team that will handle end to end production. We will achieve our targets, maintain discipline, extreme cleanliness and professionalism with the help of our shop floor engineers. Raw material management, maintenance, production management and loading/unloading of products as well.
b. Plant Engineers: This team will focus on efficient operations, supervision of the shop floor engineers and continuous production as per the orders from the buyers.
c. Quality Engineers: Every batch of production will have certain quality control procedures as stated by the buyers and the GMP Standards. These will take place in our quality control laboratory.
d. Corporate Team: This team will handle all our paperwork from incoming of goods to outgoing of our products, book-keeping, other core paperwork for the ethical establishment of our firm in the national market, overseas market and governments.
2. Construction Team: Our team that will be hired as per the details mentioned in the assurance certificate. They will handle the construction of our state of the art facility.
3. Logistics Team: Our team that will be hired as per the details mentioned in the assurance certificate will handle the logistics of our qc certified products.
4. Certificates: All the possible certificates to get our firm a credible recognition for our portfolio expansions and market reputation such as ISO 9001, soil, environment, clean water discharge, pollution and GMP certificates and any other required is what we will strive for.